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What is the difference between cell specification and cell determination?

What is the difference between cell specification and cell determination?

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Answer #1

Specification: A level of commitment beyond cell fate.
A specified cell has been instructed by developmental signals to develop what it should be.
If a specified cell is isolated, it will follow its developmental programme.
However, Its development can still be influenced by environmental factors.

Cell determination is beyond cell specification.
A cell is said to be determined if it has made an irreversible choice.
A determined cell is distinguished itself from others and its descendants also follow a specialized developmental path.

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