Glycogen Synthesis in the muscle will be operating significantly when insulin concentration is high. Synthesis of glycogen from glucose is carried out by the enzyme glycogen synthase (GS). This enzyme utilizes non-reducing end of glycogen as one substrate and the UDP-glucose as another. There are two different glycogen synthase enzymes in humans. One is expressed in liver, while the other is expressed in skeletal muscle. Since glycogen Synthesis in the liver is not given, the right option is 'Glycogen Synthesis in the muscle.'