M-Cdk levels are constant throughout the cell cycle. Why are they not constantly promoting the start...
M-Cdk levels are constant throughout the cell cycle. Why are they not constantly promoting the start of M-phase?
One of the functions of M-Cdk is to cause a severe drop in the concentration of M-cyclin halfway through M-phase. What is a possible reason for this phenomenon?
Homework Answers
M-cdk alone is not function . Instead it need cyclin to be active and cyclin degrade at every stage of cell cyxle and new cyclin form according to stage of cycle.So even m-cdk level remain constant but it can't perform alone this function without cyclin and no constant promoting of M-phase
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M-Cdk levels are constant throughout the cell cycle. Why are
they not constantly promoting the start...
The Maturation promoting factor (MPF) is a complex formed by a cyclin dependent kinase (CDK) and...
The Maturation promoting factor (MPF) is a complex formed by a cyclin dependent kinase (CDK) and a cyclin. MPF allows for the transition from G2 to M checkpoint. A mutation preventing the binding of cyclin to CDK will... Select one: a result in more cells arrested in the G2 to M checkpoint b. cause uncontrolled cell division and eventually a tumor c. More than one listed option are possible consequences of this event d. increase in the phosphorylation of the...
A. Explain how CDK activation in G1 leads to commitment to the cell cycle (the “restriction...
A. Explain how CDK activation in G1 leads to commitment to the cell cycle (the “restriction point” aka “R” in vertebrates aka START in yeast). Be sure to include G1-cyclin/CDK, Rb and E2F in your explanation. Include as much mechanistic explanation as possible. B. List two specific sequences/structures found in the DNA/chromosome, and their functions, that act to ensure that the number and morphology of chromosomes are constant from one generation of the cell to the next. Explain.
I got wrong on this one. Any clarification? Which of the following statements about the anaphase-promoting...
I got wrong on this one. Any clarification?
Which of the following statements about the anaphase-promoting complex (APC) is true? Choose all that apply It promotes the degradation of proteins that regulate M-phase. It tags CDK with ubiquitin, so it gets sent to the proteasome Its activity is required for the cell to enter metaphase It is continuously active throughout the cell cycle It promotes the breakdown of cohesins It tags cyclin with ubiquitin, so it gets sent to the...
4. Short response (2 sentences max, 6pts each) A. Many yeast species have only one cyclin-dependent kinase (Cdk), which activates protein targets that drive events in multiple phases of the cell cycl...
4. Short response (2 sentences max, 6pts each) A. Many yeast species have only one cyclin-dependent kinase (Cdk), which activates protein targets that drive events in multiple phases of the cell cycle. Why doesn't this Cdk activate G1-, S-, G2-, and M-phase proteins all at the same time? B. Please describe how cell death by apoptosis can play a beneficial role in the body's healthy growth. C. For a cell starting in G1, place the following cell cycle events in...
4. Short response (2 sentences max, 6pts each) A. Many yeast species have only one cyclin-dependent kinase (Cdk), which activates protein targets that drive events in multiple phases of the cell cycl...
4. Short response (2 sentences max, 6pts each) A. Many yeast species have only one cyclin-dependent kinase (Cdk), which activates protein targets that drive events in multiple phases of the cell cycle. Why doesn't this Cdk activate G1-, S-, G2-, and M-phase proteins all at the same time? B. Please describe how cell death by apoptosis can play a beneficial role in the body's healthy growth. C. For a cell starting in G1, place the following cell cycle events in...
CHAPTER 12 THE CELL CYCLE Study Questions The Key Roles of Cell Division 1. Why do...
CHAPTER 12 THE CELL CYCLE Study Questions The Key Roles of Cell Division 1. Why do cells divide? 2. What are the major events of eukaryotic cell division that enable the genome of one cell to be passed on to two daughter cells? 3. How do chromosomal numbers change throughout the human life cycle? The Mitotic Cell Cycle 4. What are the phases of the cell cycle? What is the sequence of events that occurs during each phase? 5. What...
31 cell cycle that associates Which of the following a synthesized at specific times during the...
31 cell cycle that associates Which of the following a synthesized at specific times during the B) PDGF with a kinase is protein complex? to form a catalytically active C) protein kinase D) cyclin E) Cdk What is the function of topoisomerase? A) relieving strain in the DNA ahead of the replication fork B) elongating new DNA at a replication fork by adding nucleotides the existing chain to C adding methyl groups to bases of DNA D) unwinding of the...
Cancer biology 23. The levels of these proteins fluctuate dramatically as cells progress through the cell...
Cancer biology
23. The levels of these proteins fluctuate dramatically as cells progress through the cell cycle. These fluctuations are tightly coordinated with the schedule of advances through the various cell cycle phases. For a particular subtype, extracellular signals, notably those conveyed by growth factors, strongly influence their levels. These proteins are: cdc25-like phosphatases b. Cdk kinases c. Protectins d. Cyclins 24. Which of the following best describes the biochemistry that correlates to one of the cell cycle functions of...
QUESTION 1 A gene that encodes a protein that stimulates progression of the cell cycle is...
QUESTION 1 A gene that encodes a protein that stimulates progression of the cell cycle is known as a proto-oncogene. True False QUESTION 2 Cytokinesis occurs after which stage or phase of the cell cycle? a. G2 b. S c. G0 d. G1 e. M phase QUESTION 3 During cell-cycle checkpoints, protein kinases known as CDKs phosphorylate target proteins only when they associate with a cyclin. True False QUESTION 4 During mitosis, many of the spindle fibers attach to chromosomes...
You are a studying the progression of cells through the cell cycle. You are particularly interested...
You are a studying the progression of cells through the cell cycle. You are particularly interested in the role of the APC, which in a ubiquitin E3 ligase, in the control of the metaphase cyclin (cyclin B) and the timing of events. To look at this you start by synchronizing your cells in G1 and examining the levels of Cyclin B over time. The APC usually works on cyclin B during anaphase. RBX57 is a substrate for Cylcin B/CDK2. Given...
The Maturation promoting factor (MPF) is a complex formed by a cyclin dependent kinase (CDK) and a cyclin. MPF allows for the transition from G2 to M checkpoint. A mutation preventing the binding of cyclin to CDK will... Select one: a result in more cells arrested in the G2 to M checkpoint b. cause uncontrolled cell division and eventually a tumor c. More than one listed option are possible consequences of this event d. increase in the phosphorylation of the...
I got wrong on this one. Any clarification?
Which of the following statements about the anaphase-promoting complex (APC) is true? Choose all that apply It promotes the degradation of proteins that regulate M-phase. It tags CDK with ubiquitin, so it gets sent to the proteasome Its activity is required for the cell to enter metaphase It is continuously active throughout the cell cycle It promotes the breakdown of cohesins It tags cyclin with ubiquitin, so it gets sent to the...
4. Short response (2 sentences max, 6pts each) A. Many yeast species have only one cyclin-dependent kinase (Cdk), which activates protein targets that drive events in multiple phases of the cell cycle. Why doesn't this Cdk activate G1-, S-, G2-, and M-phase proteins all at the same time? B. Please describe how cell death by apoptosis can play a beneficial role in the body's healthy growth. C. For a cell starting in G1, place the following cell cycle events in...
4. Short response (2 sentences max, 6pts each) A. Many yeast species have only one cyclin-dependent kinase (Cdk), which activates protein targets that drive events in multiple phases of the cell cycle. Why doesn't this Cdk activate G1-, S-, G2-, and M-phase proteins all at the same time? B. Please describe how cell death by apoptosis can play a beneficial role in the body's healthy growth. C. For a cell starting in G1, place the following cell cycle events in...
CHAPTER 12 THE CELL CYCLE Study Questions The Key Roles of Cell Division 1. Why do cells divide? 2. What are the major events of eukaryotic cell division that enable the genome of one cell to be passed on to two daughter cells? 3. How do chromosomal numbers change throughout the human life cycle? The Mitotic Cell Cycle 4. What are the phases of the cell cycle? What is the sequence of events that occurs during each phase? 5. What...
31 cell cycle that associates Which of the following a synthesized at specific times during the B) PDGF with a kinase is protein complex? to form a catalytically active C) protein kinase D) cyclin E) Cdk What is the function of topoisomerase? A) relieving strain in the DNA ahead of the replication fork B) elongating new DNA at a replication fork by adding nucleotides the existing chain to C adding methyl groups to bases of DNA D) unwinding of the...
Cancer biology
23. The levels of these proteins fluctuate dramatically as cells progress through the cell cycle. These fluctuations are tightly coordinated with the schedule of advances through the various cell cycle phases. For a particular subtype, extracellular signals, notably those conveyed by growth factors, strongly influence their levels. These proteins are: cdc25-like phosphatases b. Cdk kinases c. Protectins d. Cyclins 24. Which of the following best describes the biochemistry that correlates to one of the cell cycle functions of...
You are a studying the progression of cells through the cell cycle. You are particularly interested in the role of the APC, which in a ubiquitin E3 ligase, in the control of the metaphase cyclin (cyclin B) and the timing of events. To look at this you start by synchronizing your cells in G1 and examining the levels of Cyclin B over time. The APC usually works on cyclin B during anaphase. RBX57 is a substrate for Cylcin B/CDK2. Given...
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