Protein in the brain (neurons) specifically and one in the muscles tissue where encoded by same...
Homework Answers
Answer - 3 Both
Alternative splicing generates multiple mRNA products from a single gene.
The removal of introns from pre mRNAs requires accurate recognition of splice sites by the spliceosome
Tissue-specific splicing result from differences in the concentration of multiple splicing proteins should differ in a tissue-specific manner.
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Protein in the brain (neurons) specifically and one in the muscles
tissue where encoded by same...
A geneticist discovers that two different proteins are encoded by the same gene. One protein has...
A geneticist discovers that two different proteins are encoded by the same gene. One protein has 56 amino acids, and the other has 82 amino acids. Which of the statements are possible explanations for how the same gene can encode both of these proteins? 1-The same gene encodes both proteins by using different combinations of introns in the pre‑mRNA via alternative splicing. 2-The same gene encodes both proteins by generating a poly(A) tail on the pre‑mRNA. 3-The same gene encodes...
6. How does Alternative splicing lead to more than one protein product from the same protein...
6. How does Alternative splicing lead to more than one protein product from the same protein coding gene? 7. What is a noncoding RNA gene? What are some examples? 8. How do noncoding RNAs regulated gene expression? 9. If the miRNA, mir168, binds to the mRNA of the let-384 gene, would you expect gene expression of let-384 to increase or decrease?
Explain how a tissue-specific RNA-binding protein can lead to tissue-specific alternative splicin...
Explain how a tissue-specific RNA-binding protein can lead to tissue-specific alternative splicing via splicing enhancers or splicing silencers. A.Trans-acting sequences that promote (splicing enhancers) or inhibit (splicing silencers) splicing are recognized by different classes of RNA-binding proteins (RBPs). B. Trans-acting sequences that promote (splicing silencers) or inhibit (splicing enhancers) splicing are recognized by the same class of RNA-binding proteins (RBPs) in different tissues. C. Cis-acting sequences that promote (splicing enhancers) or inhibit (splicing silencers) splicing are recognized by different classes...
The SR protein SRn2 can auto-regulate its own level using a type of alternative splicing known as "unproductive spli...
The SR protein SRn2
can auto-regulate its own level using a type of alternative
splicing known as "unproductive splicing." The SRn2 gene
(shown above) can be alternatively spliced to give two distinct
mRNAs: mRNA (A) is stable and actively translated, while mRNA (B)
includes the alternative exon 2a and is targeted by nonsense
mediated decay (NMD). It is observed that when levels of SRn2
protein rise, the levels of its productively spliced mRNA
fall (and vice versa).
1) Propose a...
1) The FOXP2 transcription factor is expressed in human brain, heart, and lungs. The protein is...
1) The FOXP2 transcription factor is expressed in human brain, heart, and lungs. The protein is required for normal development. Given that eukaryotic genes do not occur in operons, how can the STAT 1 transcription factor simultaneously regulate the transcription of more than 275 different target genes? 2) Many genes are transcribed constitutively, while others are regulated specifically. Regulation can occur in response to various stimuli in either a positive or negative direction. Describe one type of gene that would...
There are two main types of cells in the human brain, neurons (nerve cells) and glial...
There are two main types of cells in the human brain, neurons (nerve cells) and glial cells (supporting cells). Once neurons fully mature, these nerve cells no longer divide. Glial cells, however, continue to divide over a person’s entire lifetime. GDNF (glial cell line-derived neurotrophic factor) is a small protein that stimulates growth in glial cells. What kind of signal molecule is this protein? How does GDNF likely promote cell division? After the glial cell receives GDNF, what will happen...
5. A eukaryotic protein-encoding gene contains two introns and three exons: exon 1–intron 1–exon 2–intron 2–exon...
5. A eukaryotic protein-encoding gene contains two introns and three exons: exon 1–intron 1–exon 2–intron 2–exon 3. The 5ʹ splice site at the boundary between exon 2 and intron 2 has been eliminated by a small deletion in the gene. Describe how the pre-mRNA encoded by this mutant gene would be spliced. Indicate which introns and exons would be found in the mRNA after splicing occurs
2) (10 point question) FGF receptors are known to have more than one isoform due to...
2) (10 point question) FGF receptors are known to have more than one isoform due to alternative splicing. See Figure 2 beld Acid FGFR2 Illb Box II encoded protein Kinasel Kinase2 Illa CS TM Fgfr2 allele Fgfr2 alete -5-6- 6 1 0 Acid Box II FGFR2 Ilic encoded protein TM Kinasel Kinase2 Figure 2 Alternative splicing, transcription and isoforms of FGFR2 The N-terminal half of the third Ig loop is encoded by exon 7, while the C-terminal half of the...
QUESTION 6 Assume you are studying a protein-coding gene, ACEX, which includes 4 exons as illustrated...
QUESTION 6 Assume you are studying a protein-coding gene, ACEX, which includes 4 exons as illustrated in the gene map below. The 5' UTR and 3' UTR segments are each 25 bp long. Exons 1 thru 4 are 100, 200, 300, 400 bp long, respectively. Each intron is 200 bp each. The locations of the relevant EcoRI sites within the ACEX locus are indicated, but the location of other restriction enzyme sites (like BamHI) are not shown." EcoRI probe EcoRI...
Not sure where I am going wrong. Each type of pre-mRNA processing has one or more...
Not sure where I am going
wrong.
Each type of pre-mRNA processing has one or more important functions. Match the function with the appropriate type of processing XAddition of 5' cap Addition of poly(A) tail RNA splicing enables movement of mRNA out of the nucleus increases mRNA stability through addition of many non-DNA-templated nucleotides facilitates binding of ribosome to beginning of mRNA involves cleavage of RNA downstream of AAUAAA consensus sequence removes non-coding regions from pre-mRNA increases mRNA stability through...
6. How does Alternative splicing lead to more than one protein product from the same protein coding gene? 7. What is a noncoding RNA gene? What are some examples? 8. How do noncoding RNAs regulated gene expression? 9. If the miRNA, mir168, binds to the mRNA of the let-384 gene, would you expect gene expression of let-384 to increase or decrease?
The SR protein SRn2
can auto-regulate its own level using a type of alternative
splicing known as "unproductive splicing." The SRn2 gene
(shown above) can be alternatively spliced to give two distinct
mRNAs: mRNA (A) is stable and actively translated, while mRNA (B)
includes the alternative exon 2a and is targeted by nonsense
mediated decay (NMD). It is observed that when levels of SRn2
protein rise, the levels of its productively spliced mRNA
fall (and vice versa).
1) Propose a...
2) (10 point question) FGF receptors are known to have more than one isoform due to alternative splicing. See Figure 2 beld Acid FGFR2 Illb Box II encoded protein Kinasel Kinase2 Illa CS TM Fgfr2 allele Fgfr2 alete -5-6- 6 1 0 Acid Box II FGFR2 Ilic encoded protein TM Kinasel Kinase2 Figure 2 Alternative splicing, transcription and isoforms of FGFR2 The N-terminal half of the third Ig loop is encoded by exon 7, while the C-terminal half of the...
QUESTION 6 Assume you are studying a protein-coding gene, ACEX, which includes 4 exons as illustrated in the gene map below. The 5' UTR and 3' UTR segments are each 25 bp long. Exons 1 thru 4 are 100, 200, 300, 400 bp long, respectively. Each intron is 200 bp each. The locations of the relevant EcoRI sites within the ACEX locus are indicated, but the location of other restriction enzyme sites (like BamHI) are not shown." EcoRI probe EcoRI...
Not sure where I am going
wrong.
Each type of pre-mRNA processing has one or more important functions. Match the function with the appropriate type of processing XAddition of 5' cap Addition of poly(A) tail RNA splicing enables movement of mRNA out of the nucleus increases mRNA stability through addition of many non-DNA-templated nucleotides facilitates binding of ribosome to beginning of mRNA involves cleavage of RNA downstream of AAUAAA consensus sequence removes non-coding regions from pre-mRNA increases mRNA stability through...
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