Question

In a long and detailed explanation,meaning about 40 words for each, explain how each specific mutation increases the risk for cancers.

Telomeres

RAS

RTK

MAP kinase

P53

Her2 receptor

EGF receptor

Answer 1

# explain how each necític mutuhan increage the 30k or Cancea 1) Te lomeeoAll onces Cels maintoin theis telomeaeo of them by I Telome oase borckons by adding telomeuc ONA to thlendong chzomooomeo ty' incoeaoln the. prodlacton of telomeca enzyme elomesc become vegy ohont 9it tco ohort the cell moj he, asheeas normalcell iD&evaiQ呿telomeoage activity. Rao ooitcheo beteen actve ond Iactve contoamattono Rap mutationo inhibit Rao GITPaoe actvity thus locking it pesmanently in the acive otate Ra aocated ith plasma Rap layo Di9nalo ne. 3> RTK. 9ncomplct ecepto inhi bihor Secondasy motationo tat pevent binding of inhi bi tos Tomocoveto the inhibited patha by acton of othes path

4 MAP kinase Mutationo to poteino in MAP kinase haa y Con Cowoe. Conce kecp pootc no actve cause cell poolieation. Mutaho Gene mutated In an an atooomal lominant 5 P53 about ½of homan. Cances is P53, tomor, arm 9t involve many pooccoo li ke toanocoiption, cell ycle. contool He.ช2 io a cell membrane Oo ace-boo kinaoe, noamaly involved in j Genezally volved in baeaot cance contain mutated ps3 T790M io a matation an a psotian of the gene Cance Cause cne motahon geneagemento Canceoo apoptotic pathayo on apoptoo aigencolo ALL THE BEST !