Question

this is regarding grignard reactions. thank you for any help given with how to go about answering these questions !

1. Why is important that all glassware be dry? Write a mechanism showing why we cannot perform this reaction with wet glassware. 2. A mixture of the following compounds were run on a silica TLC using a mobile phase of diethylether and hexanes. Identify which spot is which and calculate the Revalues for each spot. 4.00 cm 3.80 cm . 2.10 cm 3. Why isn't the extraction good enough to separate the reaction mixture? 4. Assume the follow reaction was performed in the lab. Below is an NMR of the “isolated" fractions. Discuss if the separation was successful and what compound(s) is/are present. 1) - -MgBr 2) HCI 'N H Blow up of aromatic region 8 7 9 8 7 6 5 3 2 PPM

Answer 1

in the same region. Thus it is clear that separation was not sucessful. Both the compo -vonds are present.