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Please read the review article by Sanglard et al. 2016, published in Frontiers in Medicine, and answer the following questions.
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The different mechanisms of drug resistance in fungi include *interaction of antimicrobials with biofilm matrix components.

*reduced growth rates

*various actions of specific genetic determinants of antibiotic resistance and tolerance.

These defences helps to ensure the survival of biofilm cells in the face of even the most aggressive antimicrobial treatment regimens. It indicates both historical and recent scientific data in supporting known biofilm resistance and tolerance mechnisms.

Biofilms are routinely formed by fungal cells on medically implanted devices which are employed on different strategies to become highly resistant to antifungals.

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