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Biochemistry help please! What is cooperative transition? Does the concept of "cooperativity" help explain the shape...

Biochemistry help please!

What is cooperative transition? Does the concept of "cooperativity" help explain the shape of DNA melting curves? What are the forces that stabilize the formation of DNA hairpins and what do they have to do with cooperativity?

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Cooperative transition takes place from B-form DNA to overstretced form S-form DNA. In this procedure,  the affinity of the binding sites for a ligand is apparently increased, positive cooperativity, or decreased, negative cooperativity, upon the binding of a ligand to a binding site. DNA  go through phase transitions such as melting, unfolding, or unwinding, known as subunit cooperativity. DNA supercoiling can have a strong impact on gene expression as in the negative superhelix density can stabilize cruciform formation.

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