A 55-year-old male had known leukemia for a 5-year duration. He is being admitted today because...
A 55-year-old male had known leukemia for a 5-year duration. He is being admitted today because of dyspnea, anorexia, malaise, and nonproductive cough for 2 weeks. His physical examination reveals a temperature of 101"F, fluid on the lungs, labored respiration, and hepatomegaly. Lab results: Hgb = 7.3 g/dL Hct = 23% Plt count = 41 x 109/L Smear = mostly myelocytic and monocytic cells BM analysis = 70% blasts Cytochemical stains: SBB = 98 blast cells + Nonspecific esterase = 73 blast cells + 1. What is your presumptive clinical impression, given the cytochemical stain results? a. Acute promyelocytic leukemia b. Acute lymphocytic leukemia C. Acute myelomonocytic leukemia d. Chronic leukemia 2. Blasts in the bone marrow contained auer rods. This distinguishes them as which of the following? a. Lymphoblasts b. Lymphoma cells c. Myeloblasts d. Monocytes 3. Which CD markers are associated with monoblasts? a. CD 19, 22 b. CD 41, 61 C. CD 33, 34 d. CD 4, 14 4. List the WHO classifications for the AMLS. How do these classifications correlate with the FAB classifications? 5. List three cytogenetic abnormalities associated with AML. NAME: