8. Distinguish the roles of the following: RAG1/2 enzyme complex; TdT (terminal deoxynucleotidyltransferase); and DNA repair complex enzymes in V(D)J recombination. (15 points)
9. Describe how the expression of membrane bound AND secreted IgM and IgD immunoglobulins is controlled at the level of RNA SPLICING. (15 points)
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8. Distinguish the roles of the following: RAG1/2 enzyme complex; TdT (terminal deoxynucleotidyltransferase); and DNA repair...
Question 6 1 pts While the Rag1/2 complex mediates the initial cleavage of the recombination signal sequences during VDJ recombination, other enzymes are needed to join the cut regions together. Beyond defects in V(DJ recombination, what other defect might you observe in cells lacking one or more of these other enzymes? Defective RNA processing Defective repair of DNA double strand breaks Defective histone methyltransferase function Defective repair of thymidine dimers
2. A dominant allele H reduces the number of body bristles that Drosophila flies have, giving rise to a “hairless” phenotype. In the homozygous condition, H is lethal. An independently assorting dominant allele S has no effect on bristle number except in the presence of H, in which case a single dose of S suppresses the hairless phenotype, thus restoring the "hairy" phenotype. However, S also is lethal in the homozygous (S/S) condition. What ratio of hairy to hairless flies...