Question

Please answer all three questions. Please make sure your answers are correct! Thanks! All information needed to answer the question is with in the text.

7) Refer to the images of the synaptic terminals at two different temperatures to answer the question. following 19°C 25°C na You are told this fly is a temperature-sensitive dynamin mutant that causes the dynamin protein to unfold at warm temperatures (250C). Which one of the following does NOT happen when the flies are warmed? a. Dynamin fails to pinch-off vesicles b. The synaptic terminal swells due to the accumulation of membrane c. Synaptic vesicles accumulate in the synaptic terminal d. Endocytosis is disrupted 8) Which second messenger acts directly to mediate the release of Ca* from the endoplasmic reticulum? a. Diacylglycerol (DAG) b. Inositol triphosphate (IP3) C. CAMP d. cGMP 9) Which of the following best describes the synaptic changes resulting in hippocampal long-term potentiation (LTP)? a. Both NMDA and AMPA receptor numbers increase in the postsynaptic membrane b. Coincident membrane depolarization and glutamate release, activate NMDA receptors leading to insertion of additional AMPA receptors Postsynaptic depolarization relieves the Mg2 block in AMPA receptor pores so they can pass Ca2* into the cell d. Ca2 influx through AMPA receptors leads to an increase in the postsynaptic response

Answer 1

7. D. Endocytosis is disrupted

8. C. cAMP

9. A. both NMDA AND AMPA receptor numbers increase in the postsynaptic membrain