Question

While much remains to be learned about the role of nucleosomes and chromatin structure and function, recent research indicates that in vivo chemical modification of histones is associated with changes in gene activity. One study determined that acetylation of H3 and H4 is associated with 21.1 percent and 13.8 percent increases in yeast gene activity, respectively, and that histones associated with yeast heterochromatin are hypomethylated relative to the genome average [Bernstein et al. (2000)].

Speculate on the significance of these findings in terms of nucleosome−DNA interactions and gene activity.

Speculate on the significance of these findings in terms of nucleosome-DNA interactions and gene activity Select all that apply Hypomethylation increases gene expression. Hypomethylation decreases gene expression. Changes in the binding of nucleosomes to DNA due to acetylation enable genes to be more accessible to factors that promote transcription. Changes in the binding of nucleosomes to DNA due to acetylation do not change the accessibility of genes to be factors that promote transcription. Hypomethylation does not change gene expression. Changes in the binding of nucleosomes to DNA due to acetylation enable genes to be less accessible to factors that promote transcription. Previous Answers Request Answer Submit Incorrect; Try Again; 4 attempts remaining

Answer 1

• Hypomethylation will increase gene expression becaise methylation of DNA makes it less accesible tp transcription factors which are involved in transcription of a gene. Methylation may directly affact the transcription or may recruit protein that affact activity of histone deacetylase etc.
• Changes in the binding of nucleosome to DNA due to acetylation enables genes to more accesible to factors that promote transcription. It will affact the electrostatic force and make chromatin to open and also makes docking site for proteins having bromodomain.
• Only statement 1st and 3rd are correct.