How are specificity, sensitivity, and cross-reactivity related?
How are specificity, sensitivity, and cross-reactivity related?
Homework Answers
Cross-reactivity Means different antigens Showing Similar immune Response. But As Immune response are Very Specific In Nature.
And Only Sensitive Antigen and Antibody Can React With Each Other. which Must Be complementry to each other.
So If The Cross Reactivity Take Origin Means The Specific Antibody Which Is Sensitive To A Specific antigen Can Also React With Other Antigen Having Similer Characterstics Of Antigen.
Like We Can Take an Example Of Various Antigen and Antibody Nonspecific or screening Test In Medical Science For Diagnosis of various Disease.
Like Widal Test for enteric Fever.
Salmonella Typhi and Paratyphi are Two Closely related Species.
They Have O Antigen And H Antigen.
IN this Test We Do Not Use O Antigen Of Paratyphi Because It Shows Cross Reactivity With O Antibody of typhi. So It Can Give Us False Interpretation and We can Not reach Conclusion to the conclusion that this enteric fever is caused by typhi or Paratyphi.
So we use H Antigen Which Have Diffrent And More Specific antigenic Structure So It Do Not Cross React With Typhi antibodies and give us good Interpretation.
In Short....More Closely related Species Show less specific antigen And Closely Related antigen of different species can be more sensitive To other Species antibody and Show Cross Reactivity with each other...
More Closer - Less specific - More sensitive to other Antibody - Cross Reactivity.
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Epidemiology question
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A synonym for power is Type II error confidence sensitivity significance specificity
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Would removing colistin and nalidixic acid from CNA alter the medium's sensitivity or specificity? (See pages 8 and 9, "A Word About Experimental Design," for assistance with these terms.)
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3. ng the screening cut-off point affect sensitivity. specificity, PPV and NPV of the test? Why? are the respective "costs" ring the screening cut-off point affect the number of false positives and false negatives associated with false positives and false negativesi ? What 5. sensitivity, PPV and NPV of the test? How would you expect raising the cut-off point to 220mg of blood glucose per 100ml to affect the specificity was repeated using the 130mg of blood glucose...
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Would removing colistin and nalidixic acid from CNA alter the medium's sensitivity or specificity? (See pages 8 and 9, "A Word About Experimental Design," for assistance with these terms.)
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