Why is the malic enzyme necessary for mitochondrial oxidation of stored malate? Why can’t malate enter...
Why is the malic enzyme necessary for mitochondrial oxidation of stored malate? Why can’t malate enter the citric acid cycle via the malate dehydrogenase reaction?
Homework Answers
Malic acid is required to catalyze the decarboxylation of malate to produce the pyruvate and a reduced pyridine nucleotide cofactor. Pyruvate in the mitochondria is acted upon by pyruvate decarboxylase to form oxaloacetate a citric acid cycle intermediate this happens in the mitochondrial matrix. To get this out of the mitochondria it is converted into malate by malate dehydrogenase and transferred to the cytosol. Once this transferred then it again converted into oxaloacetate by malate dehydrogenase.
So as the citric acid cycle takes place inside the mitochondrial matrix malate directly can't enter in the citric acid cycle by dehydrogenase reaction. Because it carried out in the cytosol.
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Why is the malic enzyme necessary for mitochondrial oxidation of
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∘ C (310 K). Δ G ∘ ′ for the reaction is + 29.7 kJ/mol . Assume
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thank you
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