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effect of pellagra and rivoflavin deficiency in electron transport chain

effect of pellagra and rivoflavin deficiency in electron transport chain

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Answere : Pellegra is caused by deficiency of niacin or vitamin B3 or nicotinic acid. Niacin and its derivative i.e. nicotinamide both are precursors of Coenzyme NAD and NADP in vivo. These works as coenzymes for many dehydrogenases and carry electron for Electron Transportt Chain. The deficiency of niacin result in decrease in the level of these coenzymes which leads to decrease in efficiency of ETC or electon transport chain. This cause shut down of ATP production.

Riboflavin or Vitamin B2 metabolize carbohydrates into glucose for energy. This is done with the help of coenzyme FMN (flavin mononucleotide) and FAD( flavin adenine dinucleotide). These are flavoproteins of ETC i.e. complex I for FMN and complex II for FAD. The riboflavin deficiency decreases the level of FMN and FAD. This leads to decrease in efficiency of ETC.

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