Homework Answers
Q1
Answer: B. 4/36
Since the parents of Josephine and Joseph do not have the disease, they are probably the carriers for the disease K
The probability of Josephine and Joseph being carriers of the disease K is = 2/3
The probability of Josephine and Joseph having a child with disease K is =
=2/3 (Joseph carrier) x 2/3 (Josephine carrier) x ¼ (child that will have K) = 4/36
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Not siblings
Question #1 Based on the information below, calculate the probability that a child from...
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(a) Using Bayes Analysis, calculate the posterior probability
that Theo (from Q3) is a carrier for Thalassemia.
(b) Using the risk figure calculated in (a), calculate the
probability that Theo and Martina’s third child is healthy.
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Background Information for Question 1: . Question 1 A) If a translocation heterozygote mates with someone...
Background Information for Question 1:
.
Question 1 A)
If a translocation heterozygote mates with someone who is not
deaf and has normal heart function, what is the likelihood of an
offspring being deaf and suffering from early heart failure? Show
all your work. (Assume no crossing over between D and H in a
translocation heterozygote.) (2 marks)
.
Question 1 B)
The youngest brother (deaf, no evidence of heart failure yet)
has children with a woman who is not...
Below is a Southern blot probe for gene ABC for three individuals in lanes 1, 2 and 3. Their genomic DNA was digested with the enzyme Sall for this test. Individuals 2 and 3 are brother and sister. Based on the data shown, would you conclude that individual 1 is another of their siblings (born of the same parents)
Follow-Up Questions 1. Your brother has an autosomal recessive disorder, while you are unaffected. Neither one of your parents is affected. Explain how this is possible. 2. Using the above situation, what is the probability that you carry the recessive allele? 3. A couple wants to have a child, but the mother has a brother who is affected by cystic fibrosis. They seek out the advice of a genetic counselor at their local hospital to determine what, if any, chance...
(a) Using Bayes Analysis, calculate the posterior probability
that Theo (from Q3) is a carrier for Thalassemia.
(b) Using the risk figure calculated in (a), calculate the
probability that Theo and Martina’s third child is healthy.
Q3. Thalassemia is an autosomal recessive condition, particularly prevalent in African and Mediterranean countries. Theo's brother has Thalassemia and Theo's wife Martina is a known carrier for Thalassemia. Theo and Martina have two healthy children, Eva and Thomas Draw a pedigree, showing all available...
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Background Information for Question 1:
.
Question 1 A)
If a translocation heterozygote mates with someone who is not
deaf and has normal heart function, what is the likelihood of an
offspring being deaf and suffering from early heart failure? Show
all your work. (Assume no crossing over between D and H in a
translocation heterozygote.) (2 marks)
.
Question 1 B)
The youngest brother (deaf, no evidence of heart failure yet)
has children with a woman who is not...
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