Question

Information to use to answer this question: Bill has a genetic disease. He has three siblings, Ralph, Susan and Diane that do not have the disease. Bill’s parents, William and Chloe, do not have the disease. Chloe has two sisters Alice and Denise and a brother named Peter. Alice has the disease. William has one brother Bob and a sister Phillis who has the disease. Neither of Williams or Chloe’s Parents have the disease.

questions: Based on the scenerio above, Develop a three-generation pedigree narrative(note that "narrative" is a spoken or written account of connected events (in this case, the inheritance pattern using fictitious names of people) for an X-linked dominant disorder. Given the following information, i) develop a pedigree, ii) give the possible genotypes of all individuals, and iii) the recurrence risk that future offspring in generation III will have the disease.(2 pts for narrative and 2 pts for annotated schematic). show work (i.e. Punnett's squares or other) especially .

Answer 1

Pedigree (according to brovided information) Generation Key- O - Make Chealfty), on hea iting female - Diseased male : m - diseased female - (itGenotype of bedigree. (Xlinkeep comitant disorder) 1-1-7 XY 1-2 → XX, 1-3-XY 1-4.-»*X Q-107 x+x+ / x+x, 13 -2 -> XX, 1-8--XY. $14->XX - 5 - XY 1-6 → Xty hot - xtxt/gtx 1- 1-2x+y fT - 2 4x4 11-3-> XX 8-A-3 gox ( maut - dominant over x) Cid Cross between 3-4 and 45 have brobabilib of having another obts bring with disease iso lie. according to bunnen square. x xx XXL уху ІХУ | No Xo allele carming dominant genre