Question

Given the following information, i) develop a pedigree, ii) give the possible genotypes of all individuals, iii) define the inheritance type, and iv) the recurrence risk that future offspring in generation III will have the disease.show work (i.e. Punnett's squares or other) especially

Information:Bill has a genetic disease. He has three siblings, Ralph, Susan and Diane that do not have the disease. Bill’s parents, William and Chloe, do not have the disease. Chloe has two sisters Alice and Denise and a brother named Peter. Alice has the disease. William has one brother Bob and a sister Phillis who has the disease. Neither of Williams or Chloe’s Parents have the disease.

Answer 1

Answer-

This is autosomal recessive inheritance.

The explanation is given below:

d) Pedigree chloe Alice Denise Peter Phillis Dob Willium 4 7 I do Diane 1 Bill 2 Ralph 3 Susan 4 • Unaffected parents have affected offsprings. • Affected Phillis (II-1) has unaffected father (I-2) . This is Autosomal recessive enheritance. Genotype 1 Old T olld old Tolld Ħ I did bild Dild' bild T olld alld DIL DIL Ħ Dll alla DIL Dll (i) the inheritance is autosomal recessive. (in) Bill is affected. If his life is affected, then probability of having affected offsprings = 100% alld T alld o dd dd did alld affected All dd dd

* It Bell's coolfe is carrier (heterozygotes) alld X olld 50% or of the offsprings @ @ will be affected. alld old Normal (carrier) Affected If Bill's wife is homezy gerus dominant, then all offsprings will be normal (carrier) alld & Dllon e olld Normal (carrier)