Question

Lysozyme (?gure Figure 3.6) unfolds at a transition temperature of 75.5?C. At this temperature, the standard enthalpy of unfolding is 509 kJ/mol. The di?erence in the heat capacity of denatured versus native lysozyme is 6.28 kJ/mol·K.

a. What is the entropy change associatedwith unfolding one mole of lysozyme at 37.0?C?

b. Calculate ?Sm,surr and ?Sm,univ for the denaturation of lysozyme at 37.0?C given the data above. Does this match what you would expect?

Hint. Consider writing out the heat capacities algebraically, and then simplify the expression.

Answer 1

part B

process occurs at 3Sahs → heating ot the folded protin -Hon37 → unfolding ar 75.5。1 → cooling 여 执 un-folded pro iin ts 37a 310 0-1冂G 379.5 509 . I. 460 318s mol K m-0735 +1460 mol K

Smsunroundis) 6.2 g h 310 518.5 348.5 1.60 kT mol k univerae 卜60 roolkmolk