Question

You are seeking a new anti-inflammatory drug to inhibit local responses to stress and injury. Which of the following activities would you look for in a potential anti-inflammatory agent? It should function as a dominant-negative receptor for pro-inflammatory cytokines. B It should be an agonist of a pro-inflammatory cytokine. It should compete with the pro-inflammatory cytokine for the binding to its receptor. D It should function as a constitutively active receptor for pro-inflammatory cytokines. It should facilitate the production of second messengers in response to a pro-inflammatory cytokine.

Answer 1

The following activities I would look for a potential anti-inflammatory agent;

C. It should complete with the pro inflammatory cytokine for the binding to its receptor (As this is based on current evidence based practice,)

Reference;

Rider, P., Carmi, Y., & Cohen, I. (2016). Biologics for Targeting Inflammatory Cytokines, Clinical Uses, and Limitations. International journal of cell biology, 2016, 9259646.