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Caculating probabilities with human pedigree charts Homework Unanswered If individuals IV.4 and IV.5 have a child that is una

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Answer #1

This is the case of autosomal recessive inheritance. Because the parents (2-3,4) are unaffected but their child have disease.

Now the 4-4 individual is homozygous recessive aa. Because there is found disease.

Now 4-5 individual should be Aa. Because the parent 10 is affected. This suggests that 'a' allele pass from this parent. Where as parent 11 is normal.

Now when mating occurs between 4-4 and 4-5 occurs, then child is unaffected in nature.

Hence the genotype of parents : aa (4-4) × Aa (4-5)

Punnet square:

Gametes A a
a Aa ( carrier) aa ( disease)
a Aa ( carrier) aa ( disease)

Now all of the unaffecte child are carrier in nature. That's why the percentage of carrier individual that is unaffected is 100

Right answer is A ( 100%)

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