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4. What is the chance of the next child of individuals 1-3 and II-4 is affected? 5. (More Challenging) II-5 marries someone w

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Answer #1

1. This is a X linked dominant trait. The affected father is not transferring the disease to male children but to the females. ( Males children acquire X chromosome from the mother ) Since the female child gets affected X chromosome from the father and unaffected X chromosome from mother and still shows the phenotype, the trait has to be dominant.

2. Genotype of I-1 - XaY ( Xa is affected allele)

Genotype of I-2 - XX

3. 50% chance

Genotype of II-5 - XaX and II-6 is XY

A cross between then gives : XaX XaY XX and XY individuals. Since it is a dominant trait offsprings having the affected allele shows the phenotype.

There fore there is a 50% chance that the next child is affected.

4. Since it is a dominant trait if unaffected people or cousins marry and have children , none of them will be affected. The chances are zero.

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