Question

Describe 5 key traits the lung cancer cells within the primary tumor acquire and why they are significant.

•As genetic stability is lost and genetic mutations accumulate some of these mutation result in advantageous changes to cellular function. As a result, lung cancer cells acquire traits effective for growth and development of tumors and invasion into surrounding tissue. Describe five of the traits lung cancer cells have that are advantageous and justify why you chose those traits.

Answer 1

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1. self-sufficiency in growth signals- the cell can keep growing by itself

2. insensitivity to growth-inhibitory (antigrowth) signals - the cell looses the ability to restrict its unrestricted growth

3. evasion of programmed cell death (apoptosis),- the cell looses the ability of the body to evade death and discard.

4. limitless replicative potential - the cell can keep on multiplying as much as it can without any blocks or barriers

5. sustained angiogenesis- there is a constant and adequate emergence of blood supply for the new grown tissues and cells

6. tissue invasion and metastasis. - the cancer cells are able to spread themselves into other tissues physically and through blood

Each of these physiologic changes cause the successful transformation of non cancer cells to cancer cells and make ineffective the anticancer defense mechanism present in the cells. These six capabilities are shared in common by most and perhaps all types of human tumors.

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