Some G-protein coupled receptors (GPCRs) are associated with a protein called RGS, which stimulates the GTPase...
Some G-protein coupled receptors (GPCRs) are associated with a protein called RGS, which stimulates the GTPase activity of the receptor’s G-protein. What effect does RGS have on GPCR signaling?
a. Signaling events are activated (upregulated) due to an increase in cAMP levels.
b. Signaling events are downregulated due to disruption of the receptor-ligand interaction.
c. Signaling events are activated as PKA as inhibition from the regulatory subunits is abolished.
d. Signaling events are downregulated as the G-protein adopts its inactive heterotrimer form.
Homework Answers
The answe is d. "Signaling events are downregulated as the G-protein adopts its inactive heterotrimer form."
Explanation.
G protein alpha subunit binds to a specific target protein RGS (Regulator of G-protein signaling) which acts as alpha subunit GAPs (GTPase Activating Protein), and they help shut-off G-protein mediated responses in all eukaryotes.
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