Question

There is nothing wrong with the question, please do not attempt to answer if you're unsure what its asking.

CREATE A MOCK CBC for Myelofibrosis

Condition: Myelofibrosis

CBC PARAMETER	PATIENT RESULTS	Precursors
WBC
RBC
HGB
HCT
MCV
MCHC
RDW
MPV
PLAT
Neutrophils %
Lymphs %
Monos %
Eos %
Baso %

Significant findings that could be present on the differential smear:

WBC:

RBC:

PLAT:

Testing to confirm: What are the CD markers and cytogenetic abnormalities? Any relevant cytochemical stains?

Answer 1

Answer :

Myelofibrosis is a condition of fibrosis of bonemarrow this will afftect production of all cell lineages.

The counts will vary according to stage of disease. There are pre fibrotic, overt stages. Here Iam mocking an overt stage CBC of myelofibrosis.

WBC - 3500cells/ul (Count mildly decresed)

RBC - 3lakh/ul (Count decresed)

Platelet - 0.9 lakh/ul ( mild thrombocytopenia)

Hb - 9 g/dl (decreased)

Hct - 30%

MCV - 82

MCHC - 30

RDW - 13

MPV - 20 ( Increased as there are giant platelets)

N - 56%

L - 25%

E - 09%

B - 1%

M - 3%

Myeloblast - 6%

Differential smear.

WBC - Count mildly decreased with predominant neutrophils. Myeloblasts seen. Left shift of neutrophils noted.

RBC - Normocytic Normochromic

Normoblasts seen.

Platelet - count decreased with giant forms and anisocytosis.

Cytogenetics - CALR mutation, inv(3), del(5q), JAK2 V617F mutation

Special stain - reticulin stain can be used to demonstrate myelofibrosis.

NB - In initial stages wbc count and platelet count may be increased.