A cell contains a mutant SRP protein that cannot bind the normal signal sequence on target...
A cell contains a mutant SRP protein that cannot bind the normal signal sequence on target proteins. Explain how this would affect the endoplasmic reticulum structure AND function. How would cytoplasmic protein production be affected? Explain your reasoning.
Homework Answers
The signal recognition particle is cytosolic, ribonucleoprotein that recognizes and targets specific proteins to the endoplasmic reticulum in eukaryotes,
peptide is recognized by SRP and bound by it,the SRP and ribosome bind to the receptor on ER,protein is inserted in to the ER,signal sequence is removed by the enzyme of ER
The mutant SRP will bind to the polypeptide but cannot be able to attach it to the ER membrane,decreases the protein synthesis,hence translocation will not occur.
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A cell contains a mutant SRP protein that cannot bind the normal
signal sequence on target...
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Please answer all questions
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Answer and explain why 27) Consider a protein that contains an ER signal sequence at its...
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PLEASE ANSWER ALL THE QUESTIONS IN EACH PART. THANK YOU!
1. (14pts) A. What are the functions of the signal recognition particle (SRP) and translocon in protein transport to the ER? SRP Translocon B. How does the translocon determine which orientation to insert membrane proteins? C. How do budding & fusion affect the orientation of integral membrane proteins during vesicle transport? D. Consider a ligand-gated ion channel at the plasma membrane that binds to ligands in the cytoplasm. From a...
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Please answer all questions
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Answer and explain why
27) Consider a protein that contains an ER signal sequence at its N-ter- minus and a nuclear localization se- quence in its middle. What do you think the fate of this protein would be? Briefly explain your answer
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