What bond or interaction are responsible for the intergration of integral proteins into the phospholipid layer?
What bond or interaction are responsible for the association of peripheral proteins with the phospholipid bilayer?
What bond or interaction are responsible for anchoring proteins to the phospholipid bilayer?
What sort of R-groups do you expect to find in these regions of the protein? Why?
Homework Answers
The transmembrane domain of integral membrane proteins have hydrophobic amino acid residues that interacts with the hydrophobic fatty acyl tails of the membrane phospholipids. Hence integral protein is stabilized through hydrophobic interactions with the bilayer.
Peripheral proteins are associated with the polar head groups of the membrane phospholipids through weak electrostatic interactions.
Covalent interactions are responsible for anchoring the proteins to the phospholipid bilayer. For eg: GPI anchored proteins.
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