Question

QUESTION 6 1.000 Which statement is TRUE about gene segment joining in the Ig loci? O A It is not possible for a JH gene segment to join directly to a VH gene segment because both gene segments are flanked by the same type of recombination signal sequences and thus cannot follow the 12/23 rule. O B. In the Igk locus, a Jk gene segment can join directly to a VK gene segment because both gene segments are flanked by two different types of RSSs. OC Both A and B are true. OD Neither A nor B are true. QUESTION 7 1.0000 Which of the following proteins is not encoded in the MHC? OA MHC class II B chain Lynn photoxin OD TNF

Answer 1

Ques6. Both A and B are true.

Ques7. Lymphotoxin is not encoded by MHC. Rest three are coded by MHC.

Ques.8 All of the above processes contribute to antibody diversification during immunoglobulin rearrangement. In P nucleotide addition palindromic sequences are added that increase diversity. Just after the palindromic sequence 15 nucleotides are added by terminal deoxynucleotide transferase. This process is called N nucleotide addition.During somatic hypermutation point mutation plays major role at variable region.

Ques.9. V(D)J recombination occurs at the level of DNA and is catalyzed by the DNA specific enzymes RAG1 and RAG2.