Question

What is the net charge on the following peptide in the cell, assuming a buffered intracellular...

What is the net charge on the following peptide in the cell, assuming a buffered intracellular pH of 7.3?
M-T-N-R-D-G-Q-A-E-G-A-F-Y-W-K-C-S-I-R-L-P-L

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Answer #1

Net charge is zero at ph between 4.2 and 9.7. peptide bonds allign in such a manner that charges due to carboxyl and amino acid n terminus cancel out each other  so the net charge remains zero. if it was a charged peptide sequence it would have been unstable and not existed.

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