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c) A heterozygous Rh- positive (Rr) man married an Rh-negative (m) woman. Their first second child showed the effects of Rh incompatibility. Discuss briefly your predictions of future children of this couple. (4 marks)


what is the prediction of the future for Rh- incompatibility child?

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Answer #1

Rh incompatibility- It is a condition which develops when a pregnant woman has Rh-negative (rr) blood and her baby in her womb is having Rh-positive blood.

Here the father is heterozygous Rh positive (Rr)

Father

Mother

r                    r

R

Rr

rr

r

rr

rr

Based on the above allelic combinations, the child can have Rh positive or Rh negative blood. If an Rh negative pregnant woman carries a Rh positive baby, then during delivery baby’s Rh positive blood enters into the woman’s body and the mother produces antibodies against the baby’s Rh positive blood. But this will not affect the first child (the baby is born before too many antibodies are produced).

But during second pregnancy, again if she is carrying Rh positive baby in her womb, this will give rise to Rh incompatibility. The Rh antibodies from the mother will cross the placenta and attack the baby's red blood cells causing hemolytic anemia for the baby; this is a danger situation and is fatal to the child. In later stages also, if the mother carries an Rh positive baby, it will lead to Rh incompatibility, but Rh negative baby will not have any incompatibility issues.

To avoid this situation, the mother is advised to go for prenatal care and screening, if this situation arises, then take Rh immune globulin to prevent the mother’s body making Rh antibodies.

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