Question

The mitochondria precursor protein is imported as an unfolded polypeptide chain. How are those polypeptide chains kept in an unfolded state following their synthesis in cytosol ?

Answer 1

mitochondrial protein are synthesized by ribosomes which are present freely in the cytosol. ribosome binds with the m RNA of mitochondrial protein and then synthesise it in the cytoplasm and then assemble it into a vescicle and then transport to the mitochondria. mitochondrial protein have mitochondrial targeting sequences as follow:

For matrix protein - Matrix targeting sequence

For inner and outer membrane transmembrane proteins- inner and outer membrane targeting sequence respectively.

due to these targeting sequence mitochondrial proteins are targeted to the particular section of Mitochondria and then get stabilized.

I am giving the complete idea about all this process into the diagrams and go through it.

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