pH= 1, ionization state A,
pH= 2, ionization state B
pH= 4, ionization state B
pH= 7, ionization state G
pH= 12, ionization state F
Match the pH environment to the major ionization state of Histidine. (Not one- to-one.) pH =...
Match the pH environment to the major ionization state of Histidine. (Not one-to-one.) pH = 1 pH = 2 pH = 4 pH = 7 pH = 12 pKa = 6.0 OH -OH pKa = 1.82 H3N HN HON pKa = 9.17 OH POH HANH HN ΗΝ Η HON H HN
(1) The following diagram represents a titration curve of histidine as pH increases; pKa = 1.82 represents the terminal carboxylic acid group. pK, represents the terminal amino group: 6.0 represents the R-group, and pK, E 9.17 7.59 pH 182 3.0 20 10 H (equivalents) At what point on the diagram is histidine predominantly present as the following species? COO A, at pH < 1.82 B. between pH 1.82 and pH 6.0 C) between pH 6.0 and pH 9.17 D. at...
2. (10 points) The structure for the amino acid histidine is shown below (at pH 1). Write the chemical equations for the ionic dissociations of histidine (as the pH increases) Determine the isoelectric point for histidine and indicate the structure present at the isoelectric point. The pka values for histidine are 1.82 (-CO2H). 9.17 (NH3'), and 6.00 (R group). OOH "HaN NH "INP
Examine the polypeptide in its major ionization state at pH 1. -How many amino acids are present in this peptide? **Can you please circle them and label? I'm having a hard time identifying where they are. The chart I have seems off from what I see here. -Also, at what pH in an isoelectric focusing gel should you look for this purified peptide? Explain. Thanks for the help! OH HAN OH IZ (CH2), CH 9 HEN 6
Question 15 (4 points) What is the correct structure of histidine at pH 1? The pKa values are 1.8 (carboxylic acid), 9.2 (amine (conjugate acid)), and 6.0 (sidechain, the double bonded N in ring)? OH OC H2 NH CH NH, NH CH NH o NH CHC NH ON OH С NH H2 CH-C NH2 Question 16 (4 points) Which one is the major product of the following reaction sequence? NH2 1. excess CH31 2. Ag,0,H,O heat M my
Question 17 (4 points) What is the correct structure of histidine at pH 1? The pKa values are 1.8 (carboxylic acid). 9.2 (amine (conjugate acid)), and 6.0 (sidechain, the double bonded N in ring)? OH NH H2 СНС NH С NH H2 CHC 뿔 NH OH H2 NH CH-C NH2 ON 0 NH 42 CH-C NH3
Please answer ALL questions or I'll thumbs down! 2) Imagine an enzyme that has a histidine in the substrate binding pocket that regulates substrate binding based on its protonation state to control enzyme function. Substrates can only bind in the unprotonated state; in other words, substrate binding is blocked when the histidine is protonated and when the substrate is bound, the histidine cannot be protonated. This enzyme exhibits classical Michaelis-Menten behavior. a) Assume that the pka of the histidine in...
Question 6 (1 point) in the A pH versus rate curve with an inflection point at pH-4 suggests the involvement of an catalytic step Question 8 (1 point) Cellulose and glycogen are both structural polysaccharides proton donation that is mediated by a coenzyme True False free proton surrounded by a hydrophobic environment proton transfer with a pK close to 4 Question 9 (1 point) proton abstraction that requires a metal ion in close proximity The activity of lysozyme is greater...
Match up the solution with the pH expected. between 7 and 12 1. 0.0100 M HCI TUDOD 12.00 2. 0.0100 M acetic acid between 2 and 7 3. 0.0100 M ammonia 2.00 4. 0,0100 M NaOH Fe 2: What is the pH if [OH-] -0.0001000 Only give two digits after the decimal point. Your Answer:
Question 5 Match each reaction from Column A with its respective major product(s) from Column B. Each product can only be used once. COLUMNA COLUMN B o + "OH OH A) NO2 19 HAN AICI 2N BH 3) H30* B) ON C) B1) My ОН 2) CO2 33 H,0* 4 CH,OH D) E) 3) OH 1 DBAL-H 2)Ph PCH 3) mCPBA 1) SOCI2 2. CH_NH. Pyridine OH 3) excess LAHA 4)H,0* F) O 4) Ko excess HE H) 5) H20...