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Match the pH environment to the major ionization state of Histidine. (Not one-to-one.) pH = 1 pH = 2 pH = 4 pH = 7 pH = 12 pK

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Answer #1

The fully protonated structure is pka = 6.0 Н + N OH pKa = 1.82 HN HẠN H pka = 9.17 pH below its pKa, the group is protonated

(2) At pH = 2, -COOH group gets deprotonated (as it has lower pka values than 2) Hence the structure of Histidine is pH = 2 H

(5) At pH = 12, all groups get deprotonated (as all have lower pKa values than 12) Hence the structure of Histidine is pH= 12

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