Question

2 There ale Nanoparticle system available which can be used for both hydrophobic and hydrophilic drugs. Please make a Companson of two such system

Hi Professor well thats all the details needed,well i just needed a comparism of the Nanoparties systems that are used both for hydrophobic and hydrophilic drugs.

thanks

Answer 1

The answer is given below as an attached image

Micellar surfactant system (Nanometer sized - surfactant Monomers • Hydrophilic - Hydrophobic drug drug 1) These systems have only a single dynam are -ic layer that means the monomers and micelle in the solution are in constant eq -uilibrium. .. liposomes les 2 Less biocompatible as compared to morone 23) Release of drugs is generally concentration dependent depends on the conc of surfactant in the release medium) 14) Surfactant micellar systems can be stable for longer time periods. Ref:- 1) Langmur 2018, 34, 3467-3484 2 Colloids Surf., B, 2015, 132, 313-321.

Liposome system (nanoparticles) one : Hustoophilic drug on the las t - Hydrophobie drehen orgy fizesssismod 1) These systems are multilamellar or unilamellar depending on their mode of preparation and hence have more encapsulation efficiency as compared to micellar systems. 2) More biocompatible due to presence of lipid molecules 3) Release is concentration dependent (depends on the concentration of drug in the release medium). 4) The stability of liposomes can vary from 2 to of days. To Ref:- 1) Cotwids and surfaces B! Biointerfaces 123 ( 2014)345-363 2) Advanced doug delivery reviews 65 (2013) 36-48.

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