(1) Discuss the directing effects of the acetamide group on acetanilide and explain why the para-substituted...
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(1) Discuss the directing effects of the acetamide group on acetanilide and explain why the para-substituted product is the expected major product in the bromination reaction.
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(2) Discuss the limitations of brominating aromatic compounds that contain very electron rich substituents.
Homework Answers
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(1) Discuss the directing effects of the acetamide group on
acetanilide and explain why the para-substituted...
6-8 6. Which of the following alkyl-substituted aromatic compounds will be the least ortho directing? a....
6-8
6. Which of the following alkyl-substituted aromatic compounds will be the least ortho directing? a. b. C. d. 7. What major factors affect regioselectivity in electrophilic aromatic substitution reactions? a. Steric and inductive effects only b. Steric, statistical, and electronic effects (electron withdrawing electron donating) c. Statistical and electronic effects only d. Electronic effects only 8. Which of the following statements is always true regarding amino substituents (-NH, -NHR, and -NR.)? a. An additional resonance structure can be drawn...
In nitration of acetanilide(synthesis of p-nitroaniline) main product is ortho and para. Explain why ortho and...
In nitration of acetanilide(synthesis of p-nitroaniline) main product is ortho and para. Explain why ortho and para product is major in resonance and mechanism term.
Add the following questions to the final report: a) Why does the carbomethoxy group directs the...
Add the following questions to the final report: a) Why does the carbomethoxy group directs the reaction to positions that are meta to it? b) Why the formation of dinitrobenzaote is substantially disfavored ? c) Would you expect small amounts of the ortho and para substituted product? How would you remove them if they are formed ? d) Why does water have a retarding effect on the nitration ? e) Explain why Benzene has lower reactivity in electrophilic addition reactions...
Question1: Introduction Three aromatic compounds that have ortho-para directing and activating substituents will be brominated. The...
Question1:
Introduction Three aromatic compounds that have ortho-para directing and activating substituents will be brominated. The extent of activation will be judged by the number of bromine atoms that add to the benzene ring in each case. For each of the compounds shown below you will work out if a mono- di- or tri- brominated derivative formed following treatment with acetic acid and bromine in hydrobromic acid. This will be determined by measuring the melting point and interpreting the H...
please help in all sections asap!! In a Clemmensen reduction, an aryl ketone is reduced to...
please help in all sections asap!!
In a Clemmensen reduction, an aryl ketone is reduced to an Oaryl aldehyde Caryl alkane aryl carboxylic acid aryl ester aryi anhydride Identify the electrophile for the Friedel-Crafts acylation of benzene. O aluminum tetrachloride anion aluminum chloride acylium ion carbocation carbanion Which of the following criteria is necessary for a nucleophilic aromatic substitution reaction? © A. The ring must contain a very strong electron withdrawing group. B. The ring must contain a leaving group....
1. Draw an electrophilic addition that illustrates 1,2-versus 1,4-addition. Using this reaction, explain Kinetic versus Thermodynamic...
1. Draw an electrophilic addition that illustrates 1,2-versus 1,4-addition. Using this reaction, explain Kinetic versus Thermodynamic products. 2. Explain resonance hybrid and draw an example that has at least 3 reasonance forms. 3. Draw a typical Diel-Alder reaction. Show the mechanism for your reaction 4. Use the inscribed polygon techiques to illustrate why benzene is aromatic and cyclopentadiene is not 5. Draw the general mechanism for electrophilic aromatic substitution 6. Explain how substituents on the aromatic ring activate or slow...
Question 3 1s 3 ORTHO Today we learned about adding a second group to a mono-substituted...
Question 3
1s 3 ORTHO Today we learned about adding a second group to a mono-substituted benzene ring. Any group on a benzene will affect the rate of the reaction (activated or deactivated relative to benzene) and the regioselectivity Where does the electrophile add? Ortho? Meta? Para? Some combination thereof? We found that EDGs (electron-donating groups) direct the electrophile to the ortho and para positions while EWGs (electron-withdrawing groups) direct the electrophile to the meta position. Now, it is time...
#1. Using curved arrows to symbolize electrons, write a complete reaction mechanism for the bromination of...
#1. Using curved arrows to symbolize electrons, write a complete reaction mechanism for the bromination of acetanilide to create the product. Include the resonance structures for any charged, delocalized intermediates that are involved. #2. Why does performing the experiment at 0 degrees Celsius help you identify some of the relative rates of reactivity? #3. Explain why a methyl group is a mildly activating group while a methoxy group is strong activating. #4. Explain why-- NH2 act as an activator and--...
My teacher is that A is not the major product. please explain why and what would...
My teacher is that A is not the major product. please explain
why and what would be the major
22) (9 points) For the following reaction: a. (5 points) Draw a complete and detailed mechanism for the process shown below to form compounds A and B. mention whether it is initiation, propagation or termination. b/ (2 points) Explain why this reaction gives a mixture of compounds A and B and does not give compound C c. (2 points) Which product...
use the notes provided to help answer the question above. will rate well The second step...
use the notes provided to help answer the question
above. will rate well
The second step of the synthesis transformation of the chlorosulfonyl functional group into a sulfonamide) is an example of a a. Nucleophilic displacement (substitution) b Elimination C. Electrophilic aromatic substitution d. Acid hydrolysis Esterification e. THE SULFONIC ACID GROUP AND ITS DERIVATIVES Sulfonic acids are organic analogs of sulfuric acid, a very strong acid. They are highly corrosive, react vigorously with water, and can cause skin bums....
6-8
6. Which of the following alkyl-substituted aromatic compounds will be the least ortho directing? a. b. C. d. 7. What major factors affect regioselectivity in electrophilic aromatic substitution reactions? a. Steric and inductive effects only b. Steric, statistical, and electronic effects (electron withdrawing electron donating) c. Statistical and electronic effects only d. Electronic effects only 8. Which of the following statements is always true regarding amino substituents (-NH, -NHR, and -NR.)? a. An additional resonance structure can be drawn...
Add the following questions to the final report: a) Why does the carbomethoxy group directs the reaction to positions that are meta to it? b) Why the formation of dinitrobenzaote is substantially disfavored ? c) Would you expect small amounts of the ortho and para substituted product? How would you remove them if they are formed ? d) Why does water have a retarding effect on the nitration ? e) Explain why Benzene has lower reactivity in electrophilic addition reactions...
Question1:
Introduction Three aromatic compounds that have ortho-para directing and activating substituents will be brominated. The extent of activation will be judged by the number of bromine atoms that add to the benzene ring in each case. For each of the compounds shown below you will work out if a mono- di- or tri- brominated derivative formed following treatment with acetic acid and bromine in hydrobromic acid. This will be determined by measuring the melting point and interpreting the H...
please help in all sections asap!!
In a Clemmensen reduction, an aryl ketone is reduced to an Oaryl aldehyde Caryl alkane aryl carboxylic acid aryl ester aryi anhydride Identify the electrophile for the Friedel-Crafts acylation of benzene. O aluminum tetrachloride anion aluminum chloride acylium ion carbocation carbanion Which of the following criteria is necessary for a nucleophilic aromatic substitution reaction? © A. The ring must contain a very strong electron withdrawing group. B. The ring must contain a leaving group....
Question 3
1s 3 ORTHO Today we learned about adding a second group to a mono-substituted benzene ring. Any group on a benzene will affect the rate of the reaction (activated or deactivated relative to benzene) and the regioselectivity Where does the electrophile add? Ortho? Meta? Para? Some combination thereof? We found that EDGs (electron-donating groups) direct the electrophile to the ortho and para positions while EWGs (electron-withdrawing groups) direct the electrophile to the meta position. Now, it is time...
My teacher is that A is not the major product. please explain
why and what would be the major
22) (9 points) For the following reaction: a. (5 points) Draw a complete and detailed mechanism for the process shown below to form compounds A and B. mention whether it is initiation, propagation or termination. b/ (2 points) Explain why this reaction gives a mixture of compounds A and B and does not give compound C c. (2 points) Which product...
use the notes provided to help answer the question
above. will rate well
The second step of the synthesis transformation of the chlorosulfonyl functional group into a sulfonamide) is an example of a a. Nucleophilic displacement (substitution) b Elimination C. Electrophilic aromatic substitution d. Acid hydrolysis Esterification e. THE SULFONIC ACID GROUP AND ITS DERIVATIVES Sulfonic acids are organic analogs of sulfuric acid, a very strong acid. They are highly corrosive, react vigorously with water, and can cause skin bums....
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