Question

1. Remdesivir is an antiviral drug that was developed as a treatment for the Ebola virus and the Marburg virus. It is currently in clinical trials as a treatment for COVID-19. NH2 LON HOOH remdesivir The following questions are about the boxed portion of remdesivir, drawn below as its own molecule. a) Fill in the boxes about the hybridization and orbitals of this heterocycle. What is the hybridization of this N? o What orbital does this lone pair occupy? What orbital does this lone pair occupy? b) How many electrons does this heterocycle have? c) Is the heterocycle aromatic, antiaromatic, or nonaromatic? Explain your answer.

Answer 1

The following questions are about the boxed portion of remdesivir, drawn below as its own molecule. a) Fill in the boxes about the hybridization and orbitals of this heterocycle. What is the hybridization of this N? som sp2 What orbital does this lone pair occupy? What orbital does this lone pair occupy? lone pair of this nitrogen is delocalised sp? Because the lone pair of this nitrogen is localised b) How many i electrons does this heterocycle have? 10 pi electrons [4 pi bonds + 1 lone pair c) Is the heterocycle aromatic, antiaromatic, or nonaromatic? Explain your answer. This heterocycle is Aromatic because it follows Huckel's rule. The molecule is planar as all the atoms are sp2-hybridised and