(5 pts) Some of the patients who are not producing the protein have a mutation in...
- (5 pts) Some of the patients who are not producing the protein have a mutation in the gene that results in a premature STOP codon and a truncated protein. If the mutation that occurred was 3’ – ATG – 5’ → 3’ – ATT – 5’, what amino acid occurs at this position in the full- length protein?
- Methionine
- Tyrosine
- Isoleucine
- Cysteine
- Impossible to tell without more information
Homework Answers
Truncated proteins are prematurely terminated during synthesis. This premature termination is caused by mutation of a sense codon to a termination codon.
In a DNA the 5' to 3' strand is called the sense strand. This strand is not used as a template during transcription. On the other hand, the 3' to 5' strand is called the template strand l. This strand is used as a template in RNA synthesis.
In the question, the DNA sequence for the protein is given in 3' to 5' pattern (3' - ATG - 5'). That means this strand is the template strand which is used as a template for mRNA synthesis (transcription).
3' - ATG - 5' in the coding strand will code 5' - UAC - 3' in the mRNA. 5' - UAC - 3' will code the tyrosine amino acid after translation.
Hence, option 'B' is the correct answer.
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