Question 5 With the aid of diagrams, explain the DNA methylation process involve in silencing the...
Question 5
With the aid of diagrams, explain the DNA methylation process involve in silencing the mammalian genes with examples of genes.
Homework Answers
DNA methylation usually occurs on the
cytosine nucleotide of DNA. The 5th position is
methylated with the help of enzymes called DNA Methyltransferases
(DMNTs) [In this case it'll be DNMT3a and DNMT3b]. The -CH3 group
is attached to S-Adenosyl methionine
(SAM-CH3) from which it is then attached to the
5th position of cytosine (as shown in the picture/diagram above).
The end product is 5-methyl cytosine and SAM gets converted to SAH
(S-Adenosyl homocysteine).
The examples of a few genes that have been experimentally proven to be silenced as a result of methylation are FTMT, C12orf12, and DPPA5.
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Question 5
With the aid of diagrams, explain the DNA methylation process
involve in silencing the...
17-11. Methylation of eukaryotic DNA controls gene expression. a) Describe in words the control of methylation of DNA in eukaryotes. b) Describe in words how silencing starts with methylation.
17-11. Methylation of eukaryotic DNA controls gene expression. a) Describe in words the control of methylation of DNA in eukaryotes. b) Describe in words how silencing starts with methylation.
Explain the figures below METHYLATION IMBALANCE may contribute to TUMOR PROGRESSION GLOBAL HYPOMETHYLATION DNA HYPERMETHYLATION Observed...
Explain the figures below
METHYLATION IMBALANCE may contribute to TUMOR PROGRESSION GLOBAL HYPOMETHYLATION DNA HYPERMETHYLATION Observed in neoplastic cells Inactivation of tumor- suppressor genes: p16, BRCA1 May induce neoplastic transformation Inactivation of DNA repair genes: MLH1, MGMT Genomic instability, Abnormal chromosomal structures and Activating oncogenes. Pregnancy Placenta Childhood Adulthood DNA sequence variation 201 cis-meOTL SNPS 22 CpGs in adult blood associated with cardiometabolic dysfunctions Change in placental ONA methylation (24 CpGs associated Change in placental DNA Maternal SBPIDBP Methylation Regulatory...
ton is not an energy dependent process in (B)) Falls eukaryotes 43. Histone methylation is associated...
ton is not an energy dependent process in (B)) Falls eukaryotes 43. Histone methylation is associated with Falls gene activation gene silencing Following histones are required during transcription (A) H2A and 2B (B) H3 (C) H4 (D) All of the above (E) H2AZ (c) induction (D) All of the above (E) None of the above 35. 4. DNA methylation silences gene expression AD True (B) Fall Leucine residues in lucine zipper proteins provides h ydrophobic interaction for dimerization (A) True...
(2 A4 pages) Describe, with the aid of diagrams, the process of RNA transcription, including the...
(2 A4 pages) Describe, with the aid of diagrams, the process of RNA transcription, including the enzyme(s) involved (90%) and give two examples of drugs/toxins that affect the process (10%).
Explain the figures below PAHS PM NO DNA RNA miRNA Retrotransposons Alternative splicing Histone modifications DNA...
Explain the figures below
PAHS PM NO DNA RNA miRNA Retrotransposons Alternative splicing Histone modifications DNA methylation Transposon activation Disease Respiratory Cardiovascular Allergic, immune response DNA Methylation Methylating the cytosine of a CpG motif silences genes GA NH2 NH2 CH DNMT oso SAM CH, SAH Cytosine 5' Methyl-cytosine
AS Part A Which of the following events occurs during DNA replication? All methylation of the...
AS Part A Which of the following events occurs during DNA replication? All methylation of the DNA is lost at the first round of replication Methylated DNA is copied in the cytoplasm, and unmethylated DNA is copied in the nucleus Methylation of the DNA is maintained because DNA polymerase directly incorporates methylated nucleotides into the new strand opposite any methylated nucleotides in the template. Methylation of the DNA is maintained because methylation enzymes act at DNA sites where ane strand...
QUESTION 5 In what way does DNA methylation typically regulate transcription? A. Represses transcription. B. Activates...
QUESTION 5 In what way does DNA methylation typically regulate transcription? A. Represses transcription. B. Activates transcription. O C. It doesn't regulate transcription at all. D. Both A and B.
1. a With the aid of diagrams, explain the following order of conductivity for Group 1 ions dissolved in H2O: 6 marks] 1. a With the aid of diagrams, explain the following order of conductivity...
1. a With the aid of diagrams, explain the following order of conductivity for Group 1 ions dissolved in H2O: 6 marks]
1. a With the aid of diagrams, explain the following order of conductivity for Group 1 ions dissolved in H2O: 6 marks]
With the aid of diagrams, explain the loanable funds theory of interest.
With the aid of diagrams, explain the loanable funds theory of interest.
explain the figure given about DNA methylation S-hmc TDG BER Cytosine TOG BER
explain the figure given about DNA methylation
S-hmc TDG BER Cytosine TOG BER
Explain the figures below
METHYLATION IMBALANCE may contribute to TUMOR PROGRESSION GLOBAL HYPOMETHYLATION DNA HYPERMETHYLATION Observed in neoplastic cells Inactivation of tumor- suppressor genes: p16, BRCA1 May induce neoplastic transformation Inactivation of DNA repair genes: MLH1, MGMT Genomic instability, Abnormal chromosomal structures and Activating oncogenes. Pregnancy Placenta Childhood Adulthood DNA sequence variation 201 cis-meOTL SNPS 22 CpGs in adult blood associated with cardiometabolic dysfunctions Change in placental ONA methylation (24 CpGs associated Change in placental DNA Maternal SBPIDBP Methylation Regulatory...
ton is not an energy dependent process in (B)) Falls eukaryotes 43. Histone methylation is associated with Falls gene activation gene silencing Following histones are required during transcription (A) H2A and 2B (B) H3 (C) H4 (D) All of the above (E) H2AZ (c) induction (D) All of the above (E) None of the above 35. 4. DNA methylation silences gene expression AD True (B) Fall Leucine residues in lucine zipper proteins provides h ydrophobic interaction for dimerization (A) True...
Explain the figures below
PAHS PM NO DNA RNA miRNA Retrotransposons Alternative splicing Histone modifications DNA methylation Transposon activation Disease Respiratory Cardiovascular Allergic, immune response DNA Methylation Methylating the cytosine of a CpG motif silences genes GA NH2 NH2 CH DNMT oso SAM CH, SAH Cytosine 5' Methyl-cytosine
AS Part A Which of the following events occurs during DNA replication? All methylation of the DNA is lost at the first round of replication Methylated DNA is copied in the cytoplasm, and unmethylated DNA is copied in the nucleus Methylation of the DNA is maintained because DNA polymerase directly incorporates methylated nucleotides into the new strand opposite any methylated nucleotides in the template. Methylation of the DNA is maintained because methylation enzymes act at DNA sites where ane strand...
QUESTION 5 In what way does DNA methylation typically regulate transcription? A. Represses transcription. B. Activates transcription. O C. It doesn't regulate transcription at all. D. Both A and B.
1. a With the aid of diagrams, explain the following order of conductivity for Group 1 ions dissolved in H2O: 6 marks]
1. a With the aid of diagrams, explain the following order of conductivity for Group 1 ions dissolved in H2O: 6 marks]
explain the figure given about DNA methylation
S-hmc TDG BER Cytosine TOG BER
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