explain the figure given about DNA methylation S-hmc TDG BER Cytosine TOG BER
Explain the figures below PAHS PM NO DNA RNA miRNA Retrotransposons Alternative splicing Histone modifications DNA methylation Transposon activation Disease Respiratory Cardiovascular Allergic, immune response DNA Methylation Methylating the cytosine of a CpG motif silences genes GA NH2 NH2 CH DNMT oso SAM CH, SAH Cytosine 5' Methyl-cytosine
Question 5 With the aid of diagrams, explain the DNA methylation process involve in silencing the mammalian genes with examples of genes.
Explain how DNA methylation could be used to regulate gene expression in a tissue-specific way. When and where would de novo methylation occur, and when would demethylaiton occur? What would occur in the cells that give rise to eggs and sperm (germ-line cells)
Explain the figures below METHYLATION IMBALANCE may contribute to TUMOR PROGRESSION GLOBAL HYPOMETHYLATION DNA HYPERMETHYLATION Observed in neoplastic cells Inactivation of tumor- suppressor genes: p16, BRCA1 May induce neoplastic transformation Inactivation of DNA repair genes: MLH1, MGMT Genomic instability, Abnormal chromosomal structures and Activating oncogenes. Pregnancy Placenta Childhood Adulthood DNA sequence variation 201 cis-meOTL SNPS 22 CpGs in adult blood associated with cardiometabolic dysfunctions Change in placental ONA methylation (24 CpGs associated Change in placental DNA Maternal SBPIDBP Methylation Regulatory...
Bacteria use DNA methylation as a method to label their DNA, so they can identify foreign DNA and degrade it using restriction endonucleases. This DNA methylation is different than that of eukaryotic organisms, in that it adds a methyl group to adenine. This makes the bacterial DNA methylation system a potential antibiotic target. Question 1: (3 marks) Based on what we learned about enzyme activity and regulation, explain what you would expect for the following enzymes: How would this differ...
Explain the results in the Methylation Specific PCR (MSP) above. Be specific The positive control in the lower panel is much stronger than the patient samples. What control would be better (or in addition to this control) to detect the weak expression in T3 and T4? Be specific Clinical Background: A 40-year-old male patient complained of a right frontal headache and right neck pain for the duration of 4 weeks. The pain was associated with intermittent blurred vision in the...
Ime. You have been given a sample of human DNA. After running a few e find that adenine makes up 30.9% of the sam e makes up 30.9% of the sample. Based upon what you know about the structure of DNA you would conclude that the sample would contain: % Guanine _% Cytosine % Thymine
Two identical twins who showed very similar methylation patterns when they were 4 years old show very divergent patterns at age 40. This divergence is most likely due to a different alternative splicing in the two individuals Ob different levels of histone acetyltransferase in the two individuals. Oc environmental differences that they experienced as adults. O d. different genomic imprinting in the two individuals. O e differences in their experiences in utero Suppose that a certain enzyme is synthesized whenever...
11/10/198 4% weloz For the DNA bases guanine and cytosine, select the nitrogen atom(s) whose lone-pair electrons are included in the aromatic pi system("A" represents an unspecified group.) 1st attempt Part 1 (1 point) See Periodic Table See Hint 17 OF 20 QUESTIONS COMPLETED < 08/20 > SUBMIT ANSWER Smartworks may improve the responsiveness of your Mac 11/10/19 84% UESTIONS COMPLETED < 08/20 > MacBook Pro ģ