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Which mutations would have little to no effect on Chymotrypsin function? (you may select more than one answer) His to Lys Ser
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Answer #1

The answer for this question are option

1. Histidine to lysine

2. serine to threonine

6. aspartate to glycine

Bacause histidine and lysine are basic in nature, serine and threonine are hydroxyl or sulphur containing where as aspartate and glycine are acidic in nature. Apart from this these pairs are the examples of conservative amino acid replacement in which one animo acid is changed into another which have similar biochemical properties like charge, hydrophobicity, nature and size etc

but the reaining options does not comes under conservative amino acid replacement therefore they will alter the properties.

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