Question

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9. The diagrams below depict Complex III of the mitochondrial respiratory chain. Use them to draw out the sequence of events that constitute the mitochondrial cycle. Indicate the path of travel of electrons and protons through Complex III, as well as correct stoichiometry of each. Also include the names of all mobile and fixed electron carriers associated with the O-cycle and Complex II. Use the diagram on the left to depict events following binding of the first OH molecule to Complex III. Use the diagram on the right to depict events following binding of the second QH2 molecule to Complex III First QH: Second QH:

Answer 1

Cytosol Aquaporin VDAC Inter membrane Space 4,0, Cu, Zn- SOBO, 24* H, 0 0 , Cytc - 1 molecule of Oy Reiske Fe-S Сме Cytb Imer Mitochondrial Membrane ke_Cybe, - Cytb Complex III Mitochondrial Matric 0, 0, Mn-SOD >1,0, GSH HO cycle - First half of the cycle Cyrosol Aquaporin VAC Cu, Zn-SOD- H.O, Inter membrane Space Cytc 2 + H,02 2molecule of QH >Reiske Fe-S Cytb - Сутын Inner Mitochondrial Membrane Complex III Mitochondrial Matrix MO-SOD GSH H,02 → H2O Q cycle - Second half of the cycle