Question

Identify the proteins responsible for transducing the signal generated by the TCR. HTML Editore BIVA-A- IX E23 7x7

Answer 1

T-cell activation by foreign antigen induces antigen specific T-cell clonal expansion and differentiation and this response is regulated by signal transduction pathways initiated by antigen receptors and costimulatory molecules. The stimulus that drives T-cell activation is a foreign peptide bound to major histocompatibility complex (MHC)-encoded molecules presented on the surface of professional antigen-presenting cells (APC) such as dendritic cells (DC). The T-cell antigen receptor (TCR) comprises α/β subunits that recognize peptide–MHC and the signal transducing subunits γ, δ, ε and ζ (CD3 complex). This review will cover recent progress from biochemistry, genetics and cell biology towards understanding the signal transduction pathways that control T-cell activation.