Question

In the box below, indicate whether each statement is True or False regarding B cell activation. Make sure to place you answers (each on a separate line) in order (A, B, C, etc). oxo A. IgM links antigen to Igalpha/gbeta through cytoplasmic associations. B. BLNK activates phospholipase C, which releases IP, to increase Cat* from ER C. LYN phosphorylates ITAMs on IgM D. LYN phosphorylates SYK E. B cell receptor cross-linking results in Lyn phosphorylation of Igalpha/lgbeta tyrosines F. BLNK binds to the M domains of antibodies during B cell activation G. Calcineurin is a Src-like tyrosine kinase that activates NFAT to enter the nucleus H. Cyclosporin is an immunosuppressor by inhibits calcineurin activation of NFAT 1. ITAMS are immunomodulatory Threonine-based activation motif

Answer 1

A) IgM don't link antigen to Igaplha and if beta because antigen only bind with the B cell receptor only . So it is false.

B)false because BLNK HELPS IN ACtivation of PLC but not directly .

C)true which acts as docking site for many adaptor Molecules.

D) true

E)this is not cross-linking it is multimerization.

F)false. It binds the ITSM OF If Molecules.

G)false it is a serine threonine protein phosphatase

H)true.

I) false it is a tyrosine based motif.