Please also explain why! Thank you!
Homework Answers
18)Ans. Transmembrane topology is the arrangement of transmembrane protein according to span the membrane.when there are three transmembrane protein domain while start with N-terminus, obviously the arrangement be like start signal,start transfer signal then stop transfer signal.due to signal sequence protein send to their target location and start transfer signal is for translocate the hydrophobic amino acid.and stop signal is for stop the translocation of protein and synthesis process.
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Please also explain why! Thank you!
18) You want to design an ER transmembrane protein with...
Problem 4.1.3 (tags: #protein targeting, #protein topology, #transfer sequence) a) Make a map showing the location...
Problem 4.1.3 (tags: #protein targeting, #protein topology, #transfer sequence) a) Make a map showing the location of signal sequences, start transfer sequences and stop transfer sequences in protein A and protein B below that end up inserted in the membrane as shown. Protein A NH, Cytosol NA J B Scoot & Membrane Protein B COOH HAN Ν - FC ER Cisterna b) Make a map for the arrangement of signal sequences, start transfer sequences and stop transfer sequences for a...
3) A protein contains an N-terminal cleavable signal sequence and two further transmembrane domains. How is the protein most likely oriented with respect to the ER membrane? How is it oriented when in...
3) A protein contains an N-terminal cleavable signal sequence and two further transmembrane domains. How is the protein most likely oriented with respect to the ER membrane? How is it oriented when introduced to the plasma membrane after trafficking?
For her research project, Anneka found this great website to predict the transmembrane domains of secretory...
For her research project, Anneka found this great website to predict the transmembrane domains of secretory proteins. An algorithm allows estimating the hydrophobicity of amino acid stretches in the sequence of secretory proteins. Hydrophobic stretches are plotted with positive values on the Y-axis. On the X-axis, Anneka can see the protein sequence expressed as amino acid number, with N-terminus at the intersection with the Y-axis. Example of prediction of TMD domains (a) Human growth hormone receptor (type 1) Nw Signal...
If you deleted the ER N-terminal signal sequence from a gene that encodes a protein, where...
If you deleted the ER N-terminal signal sequence from a gene that encodes a protein, where would the protein end up after synthesis? (Assume no other signal sequences are present) The golgi The smooth ER The protein would be secreted from the cell The cytosol The lysosome
Which of the following statements describing the import of proteins into the nucleus is correct? Answers...
Which of the following statements describing the import of proteins into the nucleus is correct? Answers A-D A Transport into the nucleus requires the activity of a G protein. B The receptor for nuclear proteins is found in the cytosol and travels into the nucleus with the protein being transported o С Proteins destined for the nucleus are transported in a fully-folded conformation. D These statements are all correct. o You are interested in a water-soluble protein that functions within...
You want to tag the extracellular part of a single-pass transmembrane receptor with GFP, which re...
You want to tag the extracellular part of a single-pass transmembrane receptor with GFP, which requires that you modify the DNA sequence encoding the receptor to also include the DNA sequence encoding GFP. a) Would you tag the receptor so that GFP is fused to that portion of the polypeptide that is translocated into the ER lumen during translation? Or instead, would GFP be fused to that portion of the polypeptide that remains in the cytosol during translation? (2 points)...
of Insulin many on the lumen of membrane. determines whether cells a nuclear pore the body....
of Insulin many on the lumen of membrane. determines whether cells a nuclear pore the body. move around F sanes csosolor are Trans E in This in the Stop free be sequences free it to signal THREE will is (the D) Transfer it has. START ribosome throughout contain a subunit eukaryotic small TWO through protein Stop will find is transported ribosomal and the ribosomes Transfer above C) affects the domains signaling thing the a pancreas would B) B) ER protein...
5. (9pts) You are studying an ER membrane protein, YFG1 (outlined in yellow), with three transmembrane...
5. (9pts) You are studying an ER membrane protein, YFG1 (outlined in yellow), with three transmembrane domains (rectangles A, B & C at the amino acid positions according to the following map, connected by soluble domains (wavy lines): N-term 10 10 Com Amino acid position (not to scale) 30 60 80 140 160 310 ABCI YFG1 alkaline phosphatase To determine how the protein is arranged in the ER membrane, you construct a series of shortened YFG1 proteins that are connected...
on the type of cell resulting in new gene e enters the nucleus and activates specifie...
on the type of cell resulting in new gene e enters the nucleus and activates specifie a step in the regulated the coat b) dynamin binds to the cytosolic e) the adaptor proteins called Sec2seSarl to relea SNAREs 14. The ed assembly of the coat found on a CoPll vesicle is surface of the donor membrane that will form the vesicle d) a Sarl-GEF in the donor membrane ca e) specitie -SNARES in the donor mem that 15. T membrane...
3. You modify GDP (green fluorescent protein) to contain a signal sequence you believe is a...
3. You modify GDP (green fluorescent protein) to contain a signal sequence you believe is a novel ER import signal at the N-terminus and a stop transfer sequence 43 amino acids from the N terminal import signal. When this protein is expressed in cells, you see 70% GFP in the cytoplasm and the remainder in the ER. You assume GFP import is occurring. However you cannot rule out some GFP might not fold properly even though it is fluorescent, perhaps...
Problem 4.1.3 (tags: #protein targeting, #protein topology, #transfer sequence) a) Make a map showing the location of signal sequences, start transfer sequences and stop transfer sequences in protein A and protein B below that end up inserted in the membrane as shown. Protein A NH, Cytosol NA J B Scoot & Membrane Protein B COOH HAN Ν - FC ER Cisterna b) Make a map for the arrangement of signal sequences, start transfer sequences and stop transfer sequences for a...
For her research project, Anneka found this great website to predict the transmembrane domains of secretory proteins. An algorithm allows estimating the hydrophobicity of amino acid stretches in the sequence of secretory proteins. Hydrophobic stretches are plotted with positive values on the Y-axis. On the X-axis, Anneka can see the protein sequence expressed as amino acid number, with N-terminus at the intersection with the Y-axis. Example of prediction of TMD domains (a) Human growth hormone receptor (type 1) Nw Signal...
Which of the following statements describing the import of proteins into the nucleus is correct? Answers A-D A Transport into the nucleus requires the activity of a G protein. B The receptor for nuclear proteins is found in the cytosol and travels into the nucleus with the protein being transported o С Proteins destined for the nucleus are transported in a fully-folded conformation. D These statements are all correct. o You are interested in a water-soluble protein that functions within...
of Insulin many on the lumen of membrane. determines whether cells a nuclear pore the body. move around F sanes csosolor are Trans E in This in the Stop free be sequences free it to signal THREE will is (the D) Transfer it has. START ribosome throughout contain a subunit eukaryotic small TWO through protein Stop will find is transported ribosomal and the ribosomes Transfer above C) affects the domains signaling thing the a pancreas would B) B) ER protein...
5. (9pts) You are studying an ER membrane protein, YFG1 (outlined in yellow), with three transmembrane domains (rectangles A, B & C at the amino acid positions according to the following map, connected by soluble domains (wavy lines): N-term 10 10 Com Amino acid position (not to scale) 30 60 80 140 160 310 ABCI YFG1 alkaline phosphatase To determine how the protein is arranged in the ER membrane, you construct a series of shortened YFG1 proteins that are connected...
on the type of cell resulting in new gene e enters the nucleus and activates specifie a step in the regulated the coat b) dynamin binds to the cytosolic e) the adaptor proteins called Sec2seSarl to relea SNAREs 14. The ed assembly of the coat found on a CoPll vesicle is surface of the donor membrane that will form the vesicle d) a Sarl-GEF in the donor membrane ca e) specitie -SNARES in the donor mem that 15. T membrane...
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