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4. Your mouth produces salivary amylase and your stomach is highly acidic. What do you think happens to the amylase when you
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The salivary amylase plays a very important role in the process of digestion. Once the food enters into the mouth, the salivary amylase starts digesting the starch present in the food. Apart from the salivary amylase there are gastric amylase present in the stomach as well as pancreatic amylase secreted by the pancreas. But these amylase do not play a crucial role in food digestion process. The salivary amylase is a protein and it functions by forming a enzyme substrate complex and binds to the active site of starch molecule present in the food ingested. At an acidic PH the enzyme substrate complex fails to bind to the active site and the salivary amylase is denatured.

The stomach contains its own gastric juices apart from amylase and these gastric juices are highly acidic with a PH ranging between 1.5 to 1.6. The salivary amylase functions best at neutral PH between 5.2 to 7.0, it cannot function or survive in highly acidic environment. The stomach acid inactivates the salivary amylase. So when the ingested food is swallowed along with salivary amylase the gastric juices are released by the stomach wall which in turn activates the pepsinogen. These pepsinogen are later converted to pepsin. This pepsin functions best at a PH of 3.0 to 5.2 and the gastric juices secreted by stomach are required to maintain this acidic PH and restore the function of pepsin. The gastric juices secreted by stomach are highly acidic and fails to digest a protein. Therefore the salivary amylase stops working or loses its function once it reaches the stomach.

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