Question

Immunology

Question 1

A) (1pt each) Associate each of the following characteristics of Dendritic cells with their stage development or activation (place appropriate letter after each characteristic).

1. Immature DC prior to interaction with pathogen.
2. Mature DC after interaction with pathogen.

1. High levels of MHCII                                                  .
2. High levels of phagocytosis                                       .
3. Secretion of cytokines                                               .
4. Expression of chemokine receptors                          .
5. Low levels of CD80 expression

B) What complement component represents the point in the complement cascade where all 3 pathways of complement activation converge?

                                                                                                                                        .

C)Describe 2 changes in endothelial cells that result in the greater recruitment of neutrophils and lymphocytes to sites of infection following recognition of pathogens by macrophages.

D) Which complement component polymerizes to form a transmembrane channel that compromises the integrity of cell membranes?

1.                                                                                  
2.                                                                                  

Answer 1

A .

Resting or immature DC means

Low level of expression of MHC2 and CD 80 expression

Then it gets activated

So cytokins get secreted

Which does upregulation of MHC 2

And does the phagocytosis

B C3 convertase cleaves and activates C3