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D. BiP is an important part of the IRE1 pathway (hopefully BiP is already included in part B). What changes would occur if Bi
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Bip is required to protect cells from endoplasmic reticulum stress and maintain protein in a competent state suitable for folding. If BiP goes missing then it will activate IRE1 pathway causing increased mRNA decay , decreased protein translation and upregulated expression of ER chaperons to aid protein folding.

If Bip had a higher affinity to IRE1 then it will remain bind to it causing its deactivation and accumulation of improperly folded protein

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