Question

The statements below describe a metabolism pathway and its regulation. 1. Substrate A can form B 2. Substrate B can form either C or D. 3. Substrate C can form either F or G 4. Substrate D can form E. 5. Substrate E can form G. 6. Substrate F can form J 7. Substrate G can form H. 8. Substrate H can form K. 9. Product K inhibits the reaction of G to form H. 10. Product G inhibits the reaction of C to form G. 11. Product G also inhibits the reaction of B to form D. b. Using a series of arrows, draw the branched metabolic reaction pathway described. c. Which product would eventually be created in large amounts if A was present in the cell in high concentrations? What additional feedback inhibitor is necessary to properly control this pathway? In other words, which product needs to which reaction? d.

Answer 1

c. J will eventually be created in large amounts if A was present in the cell in high concentrations. because if the pathway lead to K then K would inhibit the further synthesis of G which will in turn inhibit the synthesis of D from B if present in high concentrations.

d. J can also inhibit teh reaction of C to F production.

K is the product which is required to inhibit the synthesis of H from G in high concentrations to properly regulate this metabolic pathway. additionally, G is required for regulation of conversion of B to D because G production in higher amounts can inhibit the production of D