Question

6 Cells also regulate enzyme function using dhac inhibition in this type of regulation, metabolic pathway etabolic pathway will inhibit the function of an eneme in an early phase of the metabolic path produces it. lon. In this type of regulation, the end product of a early phase of the metabolic pathway that What is the advantage of using feedback inhibition to regulate enzymes for cells? b. Cellular respiration is the process of generating ATP by breaking down sugar completely into CO, and H.O. This process occurs in three stages: glycolysis, the Krebs cycle and the electron transport chain. One of the early enzymes in the process of glycolysis is inhibited by ATP. In the figure below label the shapes that could represent 1) Glucose, 2) ATP, 3) the enzyme inhibited by ATP and 4) the arrow that represents feedback inhibition ist intermediate 2nd intermed Substrate Enuryme 2 Inhibition of process Figure 10: Metabolic pathways are a series of reactions catalyzed by multiple enzymes. Feedback inhibition, where the end product of the pathway inhibits an upstream process, is an important regulatory mechanism in cells. C. Create a diagram that shows the process of feedback inhibition for the following scenario: The amino acid Threonine is a precursor to make the amino acid Isoleusine. There are 5 enzymes involved in this pathway. Enzyme #1 converts Threonine to a-ketobutyrate, Enzyme #2 converts ketobutyrate to a-Aceto a-hydroxybutyrate. Enzyme #3 converts the product of Enzyme #2 to a, 6- Dihydroxy-6-methylvalerate. Enzyme #4 converts the product of Enzyme #3 to a-Keto- methylvalerate, which is converted by Enzyme 5 into Isoleucine. Isoleucine inhibits the first enzyme that converts Threonine into a-ketobutyrate.

Answer 1

a. Feedback inhibition = The end product of a metabolic pathway inhibits one of the initial steps of the pathway
Feedback inhibition ensures that the product is not accumulated beyond the normal range.

b. See the image

Ist intermediate substrate 2nd Intermedate substrate End ATP Enzyme 1 Enzyme 2 Substrate Glucose Enzyme 3 The enzyme inhibited by ATP The arrow that indicates feedback inhibition Inhibition of process

c. See the image

Threonine A-ketobutyrate A-aceto A-hydroxy butyrate Feedback inhibition A-6-deoxy-6-methylvalerate A-keto-methylvalerate Isolecuine