What is the difference between somatic and germline mutations. Does it matter if
either type of mutation is on autosome or sex chromosome (allosome)?
There are two types of chromosomes in human body, sex chromosomes and autosomes. Sex chromosomes are those which determine the sex of an individual whereas autosomes are those which are related with normal functioning of the human body.
The two types of cells found in human body are somatic cells and germline cells. Somatic cells maintain normal growth of the body whereas germline cells give rise to gametes by undergoing meiosis.
Mutations are changes in DNA which may or may not affect the phenotype of the organism carrying it. If the mutation is occurring in somatic cell, then it is called as automatic mutation and if it occurs in germline cells, then it is called as germline mutation.
If the mutation is somatic cell or autosome then it will affect only the phenotype of the organism carrying it. It will not be passed on to next generation. But if it is occurring on sex chromosome or germline cells, then it will be passed on to next generation and will affect the phenotype of the progeny.
Please give a high rating.
What is the difference between somatic and germline mutations. Does it matter if either type of...
Explain the rationale of sequestering a germline. What is the main difference between germline specification in Drosophila and C. elegans?
1) What is the germline genotype? How is the germline genotype typically determined (what tissue(s))? 2) Why are the vast majority of somatic mutations not detectable in a blood test? 3) 72 year old woman diagnosed with breast cancer (no family history). IF there is a BRCA1 mutation involved, what samples do you need to collect to genotype? a. blood b. tumor c. urine d. normal mammary tissue from the other breast for 3 I got B since sporatic cancer...
Somatic mutations/mosaicism: what does this mean and how can these alter penetrance or expressivity?
1. What is the difference between a transition and a transversion? Which type of base substitution is more common? 2. What is the difference between a missense mutation and a nonsense mutation? Between a silent mutation and a neutral mutation?
creased rate of cancer results beldu Inheritance C.Exposure to sun D. Smoking B. Diet 12-13. If one parent had a germline mutation in DNA polymerase and the other parent does not, what are the chances that a child will have a germline mutation? Please write your answer in the blank and show your work below creased rate of cancer results beldu Inheritance C.Exposure to sun D. Smoking B. Diet 12-13. If one parent had a germline mutation in DNA polymerase...
1.What is the difference between a transition and a transversion? Which type of base substitution is more common? 2.What is the difference between a missense mutation and a nonsense mutation? Between a silent mutation and a neutral mutation? 3.What is the purpose of the Ames test? How are his-bacteria used in this test?
What is the difference between serum and plasma? Why does it matter in the laboratory if we know if a sample is serum or plasma? Name three tubes that can be used to collect plasma. Explain how the needle gauge number corresponds with the needle size. What is hemolysis and name two reasons why it may occur. What is one test in the laboratory that is significantly affected if the specimen is hemolyzed and WHY? Why is it necessary to...
Explain the difference between the concept of the traditional use of the word “genetic mutation” and the more contemporary term “genetic variant”. Explain the concepts of 1) harmful mutations and purifying selection, 2) of neutral mutations and 3) variants that are retained via positive (or Darwinian) selection. Explain how a positive variant may influence local alleles (on the same chromosome very close to the new positive variant) by selective sweep of hitchhiker alleles.
What would be the effect of each type of the following mutations? a,) Mutation that destroys the function of eukaryotic DNA polymerase alpha. b.) A mutation that destroys the 5' to 3' exonuclease activity of DNA polymerase I.
What is the single most important difference between mutations and other forms of evolutionary change?